Immune Load
Reducing immune load by clearing persistent viral, parasitic, fungal and bacterial infections.
Reducing the thromboxane cascade to clear blood clots.
Immune Load
Reducing immune load by clearing persistent viral, parasitic, fungal and bacterial infections.
Reducing the thromboxane cascade to clear blood clots.
At the root of pathogen persistence is a stagnation of multiple organ systems.
As nutrient metabolism of the body slows we have an accumulation of toxicity. Chronic pathogenic infections take hold and feast on these toxins especially heavy metals like iron for example. The vicious cycle continues as more and more pathogenic infections grip the host and drain it of energy via an up ramping of the immune system and consumption of hosts nutrients in the gut. Reducing immune load by providing the body with essential nutrients is the fastest way to clear viral, parasitic, fungal and bacterial overgrowth. In a chronic disease state the body is prioritizing these cofactors only for vital metabolic process's essential for survival. It throttles your energetic process's down to conserve the vital nutrients it has left.
Two of the most anti-pathogen / pro-host minerals are iodine and copper. Almost everyone is severely deficient in iodine with copper metabolism impaired. While restoring iodine levels with high dose iodine solution between 10 and 100mg (100 to 1000 times the RDA) it is very common to have detox symptoms as a result of bromide, fluoride and chlorine leaving the body. Bromide and fluoride are the most difficult to detoxify. These three halogens I've named block iodine receptors present in all tissues of the body. With iodine our immune system and thyroid will suffer severely as most are.
Until you have implemented these ESSENTIAL minerals into your life, however possible. Other tests/modalities/supplements should not be considered.
Iodine Solution 5 to 100mg
Zinc 10 to 30mg
Selenium 100 to 200mcg
Molybdenum 500 to 1000mcg
Copper 4 to 10mg
Magnesium 200 to 500mg
Potassium 3000mg
I provide a totally free pdf with details on how you might introduce these and how your body may respond with mitigation strategies.
The Clotting Phenomena
Individuals suffering from multiple viral infections may experience significant clotting. I believe this is because the immune system must chronically circulate antibodies throughout the system and this increases the viscosity and coagulation of the blood.
It's generally important to decrease Omega 6 dietary intake and especially important when the cardiovascular system is under stress from excess antibodies. Excess omega 6 leads to compromised cell membranes, reduced cellular fluidity, infiltration of PUFAs into the myelin sheath, neurological issues insulin resistance (diabetes), atherosclerosis, heart disease, Alzheimer's, and cancer. Omega 6 competes with Omega 3 for saturation in cardiolipin within mitochondria, impairing the cell's ability to signal CASPASE 3, an enzyme crucial for apoptosis. The speed at which these illnesses manifest can vary, partly due to genetic factors. Ideally, maintaining an Omega 3 to 6 ratio of 1:1 will partially mitigate the intensity of cytokine storms in patients with long COVID symptoms. Reducing excess Omega 6 levels in the body may take six months or more before observing noticeable improvements in metabolic health. IF METABOLISM IS SLOW IRON ACCUMULATES.
The primary biological mechanisms involved in the cleanup and dismantling of blood clots include:
Plasminogen Activation: Plasminogen is a precursor protein present in blood plasma. It gets activated into plasmin by enzymes such as tissue plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA). These enzymes are released by endothelial cells lining the blood vessels and other cells within the body. Plasmin is a potent proteolytic enzyme that breaks down fibrin, the main component of blood clots, into smaller fragments. Adequate intake of dietary protein is necessary for the synthesis of plasminogen, the precursor protein involved in fibrinolysis. Vitamin K plays a role in the synthesis of clotting factors, its use in clearing blood clots may be contraindicated.
Plasmin-Mediated Fibrinolysis: Once activated, plasmin binds to fibrin within the blood clot and cleaves it into soluble fragments called fibrin degradation products (FDPs). This process leads to the dissolution of the clot and the release of trapped red blood cells and platelets. Omega-3 fatty acids, found in fatty fish (e.g., WILD salmon, mackerel) and grass fed beef have anti-inflammatory properties and may help modulate fibrinolysis by reducing clot formation and promoting fibrinolysis. Magnesium is involved in the regulation of fibrinolysis and can help maintain normal blood clotting and dissolution processes.
Regulation of Fibrinolysis: Fibrinolysis is tightly regulated to prevent excessive bleeding or the dissolution of essential clots. Various inhibitors, such as plasminogen activator inhibitor-1 (PAI-1) and alpha-2-antiplasmin, help regulate the activity of plasminogen activators and plasmin, respectively, to ensure that fibrinolysis occurs at an appropriate rate. Antioxidant nutrients such as vitamin C, vitamin E, and selenium help protect endothelial cells and maintain their function, contributing to the regulation of fibrinolysis. Zinc regulates fibrinolysis and should always be approached with an adequate source of copper.
Endothelial Cell Function: Endothelial cells lining the blood vessels play a crucial role in regulating fibrinolysis. They release substances such as nitric oxide and prostacyclin, which promote vasodilation and inhibit platelet aggregation and clot formation. Additionally, endothelial cells produce tissue factor pathway inhibitor (TFPI), which inhibits the initiation of the coagulation cascade and helps maintain a balance between clot formation and dissolution. Nutrients such as L-arginine and L-citrulline serve as precursors for the synthesis of nitric oxide, a key molecule involved in endothelial cell function and vascular health. I would however advise caution with augmenting or stimulating nitric oxide production for those in a chronic disease state since the body will have to keep up with adequate synthesis of biopterin. Without sufficient biopterin a significant amount of super oxide may be generated. Upregulating SOD enzymes with copper and manganese can help however these actions will need to supported with hydrogen peroxide scavengers like small doses of vitamin C and PQQ.
Macrophage Clearance: Macrophages, specialized immune cells, also contribute to the removal of blood clots. They engulf and digest cellular debris, including fibrin fragments, as part of the body's natural healing and cleanup processes. Vitamin C is essential for the function of immune cells, including macrophages, which are involved in clearing cellular debris and promoting tissue repair. Citrus fruits, strawberries, and kiwi are excellent sources of vitamin C.
Strange Immune activity tilted towards the adaptive immune system response with potential energetic impairment of the innate immune response.
Iron Overload appears to be downstream from liver damage however it appears that their is also reverse causality here. Its important to isolate and eliminate sources of iron inflammation in the environment such as exposure to mycotoxins from mold that are present in water damaged buildings.
Disrupted Histamine Metabolism is a very common occurrence in those who have chronic fatigue it appears that mineral dysregulation from accumulation of heavy metals like iron, mercury, lead, arsenic and cadmium. But most importantly iron is the most significant exposure and if our metabolism of iron is disrupted it can take quite a bit of time to restart iron metabolism without the appropriate actions.
High nitric oxide levels may be an indication that the body is trying to deal with the effects of micro clots in the vasculature.
Glutamate issues may be improved with the careful introduction of manganese in the context of a mineral supplementation program.
Biotoxins from mold on our window sills, under sink, crawl space, shower, toilet, water damaged walls and spores in our carpets.
Air quality is extremely important, ideally the envelope of the home is sealed from water intrusion and their is air exchange and dehumidification in place. Water damage can easily reach the vulnerable paper backed side of drywall panels, unfortunately they can go unseen for a long time. Over half of all buildings contain mold so it is a more common problem than we realize and the complex part of this issue is that some of us can live in a water damaged building for years till we start to develop symptoms. This makes it confusing and becomes even more complex when we factor in that 25% of us have variations in the HLA set of genes that would make us additionally vulnerable to mold exposure. Past or present mycotoxin exposure left undealt with is another stressor on the back of the immune system.
Glyphosate Exposure
Glyphosate was actually originally patented as an antibiotic, and is now used as an herbicide and desiccant in many crops. Once in the human digestive tract it has been found to target good bacteria and spare the life of bad bacteria making this a serious issue for our microbiome, it also has an incredibly high affinity for copper both in the soils and in our digestive tract. This leads to a lesser amount of available copper allowing pathogens to thrive on unmanaged iron placing additional stress on the immune system.
Elemental Mercury Vapors from Mercury amalgam fillings
Glutathione gets busy binding to heavy metals like mercury making it less available for other important tasks in the body. Heavy metals block copper metabolism leading to high blood copper fooling doctors and health care practitioner into believing lies of copper toxicity.
Root Canals, Wisdom Tooth Cavitation's and Infected Necrotic Bone Tissue
Poor mineral and K2 status are leading to tooth crowding, decay, cavities, wisdom tooth extractions, root canals that can all lead to an increased risk of oral disease.
Fluoride chelates copper from the body reducing its availability for complex IV of the electron transport chain resulting in a drop of ATP causing reduced energy output by the mitochondria.
SARS-CoV-2 entry was increased in cholesterol-loaded primary macrophages and dependent, in part, on neuropilin-1. SARS-CoV-2 induced a robust inflammatory response in cultured macrophages and human atherosclerotic vascular explants with secretion of cytokines known to trigger cardiovascular events. Our data establish that SARS-CoV-2 infects coronary vessels, inducing plaque inflammation that could trigger acute cardiovascular complications and increase the long-term cardiovascular risk.
https://www.nature.com/articles/s44161-023-00336-5
Is this due to high PUFA infiltration into the tissues and oxidation of LDL leading it to be engulfed by macrophages?
While there is ongoing research in this area and the specific genetic variants associated with adverse reactions to COVID-19 vaccines are not yet fully elucidated, here are some examples of genetic variations that have been implicated in immune responses and may potentially influence vaccine reactions, along with their corresponding rs identification numbers:
HLA Genes:
HLA-DQA1: rs2187668 (associated with autoimmune diseases)
HLA-DQB1: rs2856718 (associated with autoimmune diseases)
HLA-DRB1: rs660895 (associated with autoimmune diseases)
Genes Related to Immune Response:
IL6: rs1800795 (associated with cytokine production)
IL10: rs1800896 (associated with cytokine production)
TNF: rs1800629 (associated with cytokine production)
IFNG: rs1861494 (associated with cytokine production)
CD28: rs3116496 (associated with T cell activation)
Genes Associated with Allergic Reactions:
IL4: rs2243250 (associated with allergic asthma)
IL13: rs1800925 (associated with allergic asthma)
FCER1A: rs2427827 (associated with allergic reactions)
MS4A2: rs569108 (associated with allergic reactions)
Genes Involved in Drug Metabolism:
CYP2D6: rs3892097 (associated with drug metabolism)
CYP3A4: rs2740574 (associated with drug metabolism)
ABCB1: rs1045642 (associated with drug transport)
SLCO1B1: rs4149056 (associated with drug transport)
Genetic Variability in ACE2 Receptors:
ACE2: rs2285666 (associated with expression levels)
TMPRSS2: rs12329760 (associated with expression levels)